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Primary liver cancer is one of the common malignant tumors and its mortality ranks third in the world. Because there are no obvious symptoms in the early stage of liver cancer, most patients are diagnosed as advanced stage, without the opportunity of surgical resection. The authors report a case of hepatocellular carcinoma with portal vein tumor thrombus, which reduced significantly after hepatic artery infusion chemotherapy combined with bevacizumab and atezolizumab, showing the safety and efficacy.
ABSTRACT
Objective To observe the clinical efficacy of acupuncture in treating Oxycodone hydrochloride-induced constipation in cancer pain patients.Method Sixty cancer pain patients with Oxycodone hydrochloride-induced constipation were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by acupuncture, while the control group was by oral administration of lactulose oral solution. The therapeutic efficacies were compared after 2-week treatment, and the quality of life was evaluated before and after treatment.Result The total effective rate was 90.0% in the treatment group versus 73.3% in the control group, and the difference was statistically significant (P<0.05). The Karnofsky Performance Status (KPS) score was significantly changed in the treatment group after intervention (P<0.05). There was a significant difference in comparing the KPS score between the two groups after treatment (P<0.05).Conclusion Acupuncture can produce a significant efficacy in treating Oxycodone hydrochloride-induced constipation, and also improve the patients’ quality of life.
ABSTRACT
Objective To explore the risk factors of local relapse and distant metastasis after radical resection of lung adenocarcinoma.Methods A total of 102 patients with lung adenocarcinoma operated in First Affiliated Hospital of Xinjiang Medical University from January 2005 to January 2010 were collected.The correlation between clinicopathological characteristics and prognosis was evaluated by single-factor and multi-factor analyses.The survival curves were plotted using Kaplan-Meier.Single-factor analysis of statistical difference was tested using Log-rank test.Multi-factor analysis of prognostic factors were produced by COX regression proportional hazards model.Results In the whole group,1,2,3 and 5 year disease-free survival rates were 74.30％,58.00％,51.50％ and 44.90％ respectively,and the median disease-free survival was 30 months.Single-factor analysis showed that tumor size (x2 =9.951,P =0.002),clinical type (x2 =8.460,P =0.004),differentiated degree (x2 =4.807,P =0.028),lymph node metastasis (x2 =40.516,P =0.000),pathological stage (x2 =38.769,P =0.000) were prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma.Muti-factor analysis showed that tumor size (OR =1.943,95 ％ CI:1.091-3.463,x2 =5.082,P =0.024),differentiated degree (OR =2.570,95 ％ CI:1.451-4.552,x2 =10.467,P =0.001),lymph node metastasis (OR =3.196,95％ CI:1.037-9.849,x2 =4.096,P =0.043) were independent prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma.Conclusion Tumor size,differentiated degree and lymph node metastasis are independent prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma.